MOTS-c Frequently Asked Questions
Short answers first, with links to the full explanation.
Last reviewed and updated:
What is MOTS-c?
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded in mitochondrial DNA.[1] See the full guide.
Who discovered MOTS-c?
MOTS-c was reported in 2015 by Lee and colleagues at the University of Southern California.[1]
How many amino acids are in MOTS-c?
MOTS-c has 16 amino acids.
What is the MOTS-c sequence?
The reported sequence is MRWQEMGYIFYPRKLR.[1]
What is the molecular weight of MOTS-c?
About 2,174 daltons, calculated from the sequence.
Has MOTS-c been studied in humans?
Only to a limited extent, mostly measurements of natural MOTS-c and genetic association studies.[3] See human research.
What is AMPK?
AMPK (AMP-activated protein kinase) is a cellular energy sensor enzyme. MOTS-c has been associated with AMPK signaling in preclinical studies.[1]
What is a peptide COA?
A certificate of analysis is a report of test results for a specific lot. See the COA guide.
How are purity and identity evaluated?
Purity is commonly estimated by HPLC and identity by mass spectrometry. See testing.
Where can MOTS-c be sourced for laboratory research?
MOT-C.com links to DISSOLV LABS as its commercial research-use source for MOTS-c. See research sourcing.